Annual report pursuant to Section 13 and 15(d)

License Agreements (Details Textual)

v3.6.0.2
License Agreements (Details Textual) - USD ($)
1 Months Ended 2 Months Ended 12 Months Ended
May 31, 2016
Sep. 30, 2015
May 31, 2015
Mar. 31, 2015
Dec. 31, 2014
Dec. 31, 2016
Dec. 31, 2015
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Stock Issued During Period, Value, Issued for Services           $ 14,000 $ 1,269,000
Proceeds from Issuance of Common Stock         $ 0 570,000 51,496,000
Neupharma [Member]              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Payment Of Upfront Fees       $ 1,000,000      
Reimbursement Of Cost Recognized As Revenue           1,000,000  
Payment For Non refundable Milestone payments           1,000,000  
Neupharma [Member] | Additional Sales Milestone [Member]              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Maximum Potential Milestone Payments           22,500,000  
Neupharma [Member] | Clinical Development Milestone [Member]              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Maximum Potential Milestone Payments           40,000,000  
Neupharma [Member] | Regulatory Approvals To Commercialize The Products [Member]              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Maximum Potential Milestone Payments           40,000,000  
Dana-Farber [Member]              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Shares Issued, Price Per Share     $ 0.065        
Stock Issued During Period, Shares, Issued for Services   136,830 500,000        
Stock Issued During Period, Value, Issued for Services   $ 600,000 $ 32,500        
Payment Of Upfront Fees       $ 1,000,000      
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners     5.00%        
Proceeds from Issuance of Common Stock   $ 10,000,000          
Dana-Farber [Member] | First Commercial Sale Milestone [Member]              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Revenue Recognition Milestone Method, Payments Due           21,500,000  
Maximum Potential Milestone Payments           21,500,000  
Dana-Farber [Member] | Additional Sales Milestone [Member]              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Revenue Recognition Milestone Method, Payments Due           60,000,000  
Maximum Potential Milestone Payments           60,000,000  
Teva Pharmaceutical Industries Ltd [Member]              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Payment Of Upfront Fees           500,000  
Teva Pharmaceutical Industries Ltd [Member] | Clinical Development Milestone [Member]              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
License Expense           206,500,000  
Teva Pharmaceutical Industries Ltd [Member] | Regulatory Approvals To Commercialize The Products [Member]              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
License Expense           220,000,000  
Jubilant Biosys Ltd [Member]              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Payments for Other Fees $ 1,000,000            
Payment Of Upfront Fees 2,000,000            
Revenue Recognition Milestone Method, Payments Due $ 87,500,000            
Revenue Recognition, Milestone Method, Revenue Recognized           1,500,000  
Research and Development Cost, Shared Percentage 50.00%            
Jubilant Biosys Ltd [Member] | Clinical Development Milestone [Member]              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Maximum Potential Milestone Payments           89,000,000  
Jubilant Biosys Ltd [Member] | Regulatory Approvals To Commercialize The Products [Member]              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
License Expense $ 59,500,000            
Jubilant Biosys Ltd [Member] | Successful Achievement Of One Preclinical Milestone [Member]              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Revenue Recognition Milestone Method, Payments Due 300,000            
Jubilant Biosys Ltd [Member] | Completion Of Three Clinical Development Milestones For Two Licensed Products [Member]              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Revenue Recognition Milestone Method, Payments Due 25,500,000            
Jubilant Biosys Ltd [Member] | Five Regulatory Approvals And First Commercial Sales [Member]              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Maximum Potential Milestone Payments 61,700,000            
Jubilant Biosys Ltd [Member] | Three Sales Milestones Based On Aggregate Net Sales [Member]              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Revenue Recognition Milestone Method, Payments Due 89,000,000            
Jubilant Biosys Ltd [Member] | Sale Millstone [Member]              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
License Expense $ 89,000,000            
Collaboration Agreement With TGTX [Member]              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Revenue Recognition, Milestone Method, Revenue Recognized           42,000 $ 500,000
Payment Of Upfront Licensing Fee           500,000  
Collaboration Agreement With TGTX [Member] | Clinical Development Milestone [Member]              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Revenue Recognition Milestone Method, Payments Due           7,000,000  
Collaboration Agreement With TGTX [Member] | Commercial Sales In Specified Territories [Member]              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Revenue Recognition Milestone Method, Payments Due           $ 14,500,000