Annual report pursuant to Section 13 and 15(d)

Stockholders' Equity (Details Textual)

v3.8.0.1
Stockholders' Equity (Details Textual) - USD ($)
1 Months Ended 12 Months Ended
Oct. 04, 2017
Mar. 17, 2017
Feb. 29, 2016
Mar. 31, 2015
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Mar. 12, 2018
Nov. 30, 2017
Mar. 17, 2016
Mar. 17, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Common Stock, Shares Authorized         50,000,000 50,000,000          
Common Stock, Par or Stated Value Per Share         $ 0.0001 $ 0.0001          
Common Stock, Shares, Issued         18,512,429 17,426,876          
Share-based Compensation         $ 3,117,000 $ 3,867,000 $ 3,252,000        
Equity Method Investment, Annual Equity Fee, Percentage                     2.50%
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross         0            
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Share-based Awards Other than Options         $ 2,900,000            
Issuance of Stock and Warrants for Services or Claims         $ 0 $ 14,000 1,269,000        
Shelf Registration Statement, Maximum Authorized Securities                 $ 100,000,000    
Agent [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Commission rate         3.00%            
Subsequent Event [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Shelf Registration Statement, Remaining Authorized Securities               $ 77,000,000      
2015 Incentive Plan [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant         2,961,697            
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period         10 years            
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized         5,000,000            
Restricted Stock [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number         2,611,116 2,533,063          
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period         359,303            
Non-vested Resricted Stock [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition         1 year 2 months 12 days            
Performance Shares [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number         333,334            
Dr. Marasco [Member] | Share-based Compensation Award, Tranche One [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period       48 months              
Percentage of award vested on first anniversary date       25.00%              
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross       1,500,000              
Dr. Marasco [Member] | Restricted Stock [Member] | 2015 Incentive Plan [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period 139,303                    
Percentage of shares granted on diluted equity outstanding 0.50%                    
General and Administrative Expense [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Share-based Compensation         $ 1,800,000 $ 1,300,000 300,000        
Research and Development Expense [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Share-based Compensation         226,000 58,000          
Issuance of Stock and Warrants for Services or Claims         2,300,000 3,900,000          
Research and Development Expense [Member] | Grant [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Share-based Compensation         $ 900,000 2,500,000 $ 3,000,000        
Opus Point Healthcare Fund GP, LLC [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Proceeds from Issuance of Private Placement     $ 600,000                
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right     3,500                
Class of Warrant or Right, Exercise Price of Warrants or Rights     $ 7.00                
Stock Issued During Period, Shares, New Issues     126,640                
Number Of Warrant Issued     44,324                
Sale of Stock, Number of Shares Issued in Transaction     10,000                
Sale of Stock, Consideration Received on Transaction     $ 45,000                
Fortress Biotech, Inc [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Stock Issued During Period, Shares, New Issues   721,699 3,166   721,699            
Share-based Compensation           $ 14,000          
Equity Method Investment, Annual Equity Fee, Percentage     2.50%   2.50%         2.50%  
Common Class A [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Common Stock, Shares Authorized         15,000,000            
Common Stock, Shares, Issued         7,000,000 7,000,000