Annual report pursuant to Section 13 and 15(d)

Stockholders' Equity (Details 3)

v3.8.0.1
Stockholders' Equity (Details 3) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Employee Benefits and Share-based Compensation $ 3,117 $ 3,867 $ 3,252
Research and development      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Employee Benefits and Share-based Compensation 1,180 2,557 2,987
General and administrative      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Employee Benefits and Share-based Compensation $ 1,937 $ 1,310 $ 265