Quarterly report pursuant to Section 13 or 15(d)

Stockholders' Equity (Details 3)

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Stockholders' Equity (Details 3) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Employee Benefits and Share-based Compensation $ 1,127 $ 910 $ 2,336 $ 4,271
Research and development        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Employee Benefits and Share-based Compensation 642 446 930 2,798
General and administrative        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Employee Benefits and Share-based Compensation $ 485 $ 464 $ 1,406 $ 1,473